Size of immune cell represents relative abundance.

However, T-lymphocytes and dendritic cells are typically inhibited and defective, respectively. Degranulated mast cells, neutrophils, dendritic cells and B- and T-lymphocytes are also present. Additionally, there is an increased presence of macrophages, and T- and B-lymphocytes, and further degranulation of mast cells D: Development of pancreatic intraepithelial neoplasias and subsequent PDAC leads to a significant increase in immunosuppressive cell types including tumor-associated macrophages, myeloid-derived suppressor cells, and Tregs. Pancreatic mast cells begin to degranulate C: CP is characterized by development of stroma surrounding degranulated acinar cells, acinar-to-ductal metaplasia and edema. Figure 6 Immune cells in progressive pancreatic disease.Ī: The normal pancreas contains sparse, mostly innate, inflammatory cells and lacks the dense stroma typically seen in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) B: Acute pancreatitis (AP) is characterized by acinar degranulation, edema and recruitment of mostly innate inflammatory cells, but also some T-lymphocytes in response to acinar damage.